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Platelet Biology Group

 

Artificial Marrow Niche

Currently, in vitro blood cell formation for transfusion purposes is hampered by the inability to obtain end-stage mature cells. The bone marrow niche provides essential cues for blood cell maturation. We aim to recreate these cues, using a GMP-compatible method to translate into future...

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Blood Cell Production

Human pluripotent stem cells (hPSC) can be maintained and expanded in vitro for prolonged periods and can be induced to differentiate towards virtually any cell type. Therefore, they offer huge opportunities for basic research and clinical applications. Platelets and red cells are enucleated and...

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Clinical Research

Our team applies statistical and computational methods to discover new genes and molecular mechanisms that control platelet life and function in health and disease. We translate this knowledge into the clinic by developing comprehensive and cost effective DNA tests to improve the diagnosis of...

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Epigenomics

Our team spearhead the healthy samples collection for the European consortium Blueprint by making use of the NIHR Cambridge Bioresource volunteers. The aim of this consortium is to generate reference epigenomes for all the cell types present in the blood as part of the International Human Epigenome...

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Functional Cell Biology

Platelet Functional Assays Individuals with reduced platelet count or function have bleeding tendencies, whereas those with elevated values are at greater risk of heart attacks and stroke. Interindividual variation in platelet parameters like their function, count, and volume is to a large extent...

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Model Organisms

Jak2 V617F myeloproliferative neoplasms . The JAK2 V617F mutation is present in 90% and 50% of patients with Polycythaemia Rubra Vera and Essential Thrombocythaemia respectively. The clinical hallmark of these conditions is an increased red cell/platelet count and increased risk of cardiovascular...

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Statistical Genomics

The Genetic Aetiology of Rare Diseases NIHR Bioresource Key people: Dr Chris Penkett , Dr Roger James , Sofie Ashford The National Institute of Health Research has established a BioResource for Rare Diseases . Our group is responsible for the recruitment of patient participants to this resource...

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