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Platelet Biology Group

Latest news

New study increases the number of known genetic variants associated with blood indices by factor of 10

20 November 2016

A genome-wide association study of clinical full blood count indices measured in 173,480 people has identified independent associations with over 2,700 genetic variants

BBC: Huge leap to mass produced platelets

19 April 2016

Scientists have made a significant leap towards mass producing platelets - the part of the blood that forms clots.

New paper on artificial production of platelet precursor cells

19 April 2016

Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming

Platelets are blood cells that maintain the integrity of the vessel wall and respond to vascular damage. Although they were discovered in the mid-19th century, we are still largely ignorant about the molecular mechanisms that regulate their formation and function. The principal aim of our research is to identify and characterise these mechanisms. This fundamental science is applied to improve treatments for life-threatening diseases such as heart attack and stroke. Our research depends on molecular studies of blood cells and their progenitors, genome-wide association scans, rare disease genome sequencing studies, model organism research and clinical trials. We also study approaches for generating platelets from pluripotent stem cells in the laboratory with the aim of replacing classic donor-derived platelet concentrates and the aim of generating platelets with specific functional features.

Our research is supported by:



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Marie Curie

Evelyn Trust