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Professor Willem Ouwehand

The Ouwehand group focuses on human megakaryocyte and platelet biology. Our primary interest is in unravelling the relationship between sequence variation and its effect on platelets. The group is part of the Department of Haematology at the University of Cambridge and is embedded within the NHS Blood and Transplant. We collaborate with the Wellcome Trust Sanger Institute (WTSI) and the European Bioinformatics Institute (EBI) as well as many leading academic institutions the world over.


Dr Cedric Ghevaert

The Ghevaert research group is based at the Cambridge Blood Centre, NHS Blood and Transplant (NHSBT). Our research programme is focused on the production of platelets and megakaryocytes in vitro from haematopoietic stem cells (HSCs) or pluripotent stem cells (PSCs). The group has a keen interest in translating biological discoveries into applications for transfusion medicine and uses a multidisciplinary approach that encompasses cell biology, engineering, and computational biology.


RSS Feed Latest news

BBC: Huge leap to mass produced platelets

Apr 08, 2016

Scientists have made a significant leap towards mass producing platelets - the part of the blood that forms clots.

New paper on artificial production of platelet precursor cells

Apr 07, 2016

Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming

New paper describing a gain-of-function variant in SRC features in this week's cover of Science Translational Medicine

Mar 02, 2016

Hyperactive SRC yields thrombocytopenia, myelofibrosis, bleeding, and bone pathologies

New statistical method, SimReg, for identifying the genetic causes of rare diseases published in the AJHG.

Feb 25, 2016

NIHR/BSU collaboration leads to new statistical method, SimReg, for identifying the genetic causes of rare diseases.

New paper on a gain-of-function variant in DIAPH1 that causes dominant macrothrombocytopenia and hearing loss

Feb 25, 2016

A gain-of-function variant in DIAPH1 is associated with macrothrombocytopenia and hearing loss and extends the spectrum of DIAPH1 related disease.

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Platelets are blood cells that maintain the integrity of the vessel wall and respond to vascular damage. Although they were discovered in the mid-19th century, we are still largely ignorant about the molecular mechanisms that regulate their formation and function. The principal aim of our research is to identify and characterise these mechanisms. This fundamental science is applied to improve treatments for life-threatening diseases such as heart attack and stroke. Our research depends on molecular studies of blood cells and their progenitors, genome-wide association scans, rare disease genome sequencing studies, model organism research and clinical trials. We also study approaches for generating platelets from pluripotent stem cells in the laboratory with the aim of replacing classic donor-derived platelet concentrates and the aim of generating platelets with specific functional features.

Our research is supported by: